KMID : 0357920040380010008
|
|
Korean Journal of Pathology 2004 Volume.38 No. 1 p.8 ~ p.14
|
|
Expression of CD43 in Colorectal Adenocarcinoma
|
|
Jung Kyeong-Cheon
Bae Young-Mee Ahn Hye-Kyung Kim Hye-Eun Jang Myung-Chul Roh Hye-Rin Chae Gi-Bong Choi Won-Jin Kim Woo-Jin Park Weon-Seo
|
|
Abstract
|
|
|
Background: CD43 is a sialoglycoprotein that is highly expressed on most leukocytes, except on B lymphocytes and dendritic cells. CD43 has been reported to be involved in the adhesion and apoptosis of lymphocytes. Although the aberrant expression of CD43 antigen in non-lymphoid tissues has been reported, the expression of the CD43 antigen in gastrointestinal malignancies is not well studied. Here, we studied the expression of CD43 in colon adenocarcinoma using the anti-CD43 monoclonal antibody developed in our laboratory.
Methods: Thirty patients who had undergone surgical resection for colorectal carcinoma were recruited. The expression of CD43 molecule was determined by analyzing the formalin-fixed, paraffin-embedded specimens immunohistochemically using our newly developed anti-CD43 mAb (K06). The results obtained by the immunohistochemical analysis correlated to the clinicopathological parameters.
Results: The expression of CD43 were found in 20 out of 30 colorectal carcinoma cases. The expression of CD43 antigen is higher in well differentiated adenocarcinomas than poorly or moderately differentiated adenocarcinomas.
Conclusions: The new anti- CD43 mAb might be helpful for the detection of the expression of CD43 on colorectal carcinoma cells. Further studies are required to assess the relationship between the CD43 expression and the colorectal carcinogenesis.
|
|
KEYWORD
|
|
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|